Six & Twenty Carolina Cream is a handcrafted cream liqueur from Six & Twenty Distillery in Powdersville, South Carolina. It blends 5-grain bourbon with all-natural cream, rum, and a carefully chosen blend of spices to create what fans have called "liquid dessert." The result is a rich, smooth spirit at 17% ABV (34 proof) with notes of vanilla, caramel, and chocolate.

Exceptional served over ice, stirred into coffee or an espresso martini, blended into eggnog, or mixed with peanut butter whiskey for creative cocktails. Its approachable sweetness and depth have made Carolina Cream the most popular expression in the Six & Twenty lineup. The recipe was born when the distillery owner's mother-in-law requested an Irish cream for Christmas, inspiring the team to craft something distinctly Southern and better.