Frontline Plus Flea and Tick Dog Treatment provides 8 months of comprehensive protection for small dogs weighing 5 to 22 lbs. This veterinarian-recommended topical solution contains two active ingredients: fipronil (9.8%) and (S)-methoprene (8.8%), which work together to kill adult fleas, flea eggs, flea larvae, ticks, and chewing lice.

Fipronil kills adult fleas and ticks by interrupting their GABA-regulated nerve channels, causing neurologic overexcitement and death in parasites. (S)-methoprene is an insect growth regulator that targets flea eggs and larvae, interrupting their life cycle and preventing new adult fleas from developing. The product collects in the oils of your dog's skin and hair follicles, providing continuous 30-day protection per application through a process called translocation that spreads the medication over the body in about 24 hours.

Frontline Plus kills ticks that may transmit Lyme disease, Rocky Mountain spotted fever, ehrlichiosis, babesiosis, anaplasmosis, and other tick-borne diseases. The treatment remains effective after bathing or swimming, though shampooing should be avoided within 48 hours of application. Less than 1% of the medication is absorbed into your dog's body, meaning it does not interact with other medications and is safe for use in breeding, pregnant, or nursing dogs. Suitable for puppies 8 weeks of age and older weighing at least 5 lbs.