Frontline Plus is a topical flea and tick treatment for large dogs weighing 45-88 pounds, providing an 8-month supply with 7+1 doses. This fast-acting formula contains two active ingredients, fipronil (9.8%) and (S)-methoprene (8.8%), which work together through dual-action to kill adult fleas, flea eggs, flea larvae, ticks, and chewing lice.

The treatment works by disrupting the nervous system of parasites through contact with your pet's coat, requiring no biting. Fipronil migrates across the dog's body through translocation within 24 hours, stored in oil glands beneath the skin for continuous surface protection. (S)-methoprene prevents flea egg production and hatching while inhibiting larval development, breaking the flea life cycle. The formula kills 100% of fleas within 12 hours of application and provides 30 days of continuous protection per dose.

Application is simple: part the fur at the base of the neck and apply the liquid directly to the skin. The treatment becomes waterproof 24 hours after application, allowing dogs to swim and bathe without reducing effectiveness. Not suitable for puppies under 8 weeks of age. Wash hands thoroughly after application and keep away from eyes and mouth.