The House of Cross is the thirty-third novel in James Patterson's globally bestselling Alex Cross thriller series, published November 25, 2024 by Little, Brown and Company (Hachette Book Group). The hardcover edition runs 416 pages.

In this action-packed thriller, Supreme Court candidates are being systematically murdered across Washington, DC. As the president-elect selects the country's brightest legal minds for the highest court in the land, a diabolical killer begins targeting them one by one — gunned down, stabbed, and assassinated in the streets. FBI consultant and criminal psychologist Detective Alex Cross is called in to stop the killer before more lives are lost. But the case takes a devastating personal turn when Cross's wife, Bree, and his best friend, John Sampson, go missing. With everything he loves on the line, Cross must pursue three desperate goals: find Bree and John, escape, and survive.

The book is also the inspiration for the hit streaming series Cross on Prime Video, starring Aldis Hodge as Alex Cross. The series has been praised for Patterson's ability to craft relentlessly paced narratives that combine police procedural realism with deeply personal stakes.