The House of Cross is the thirty-third installment in James Patterson's bestselling Alex Cross thriller series, published November 25, 2024, by Little, Brown and Company, an imprint of Hachette Book Group. This hardcover edition runs 416 pages and carries ISBN 9780316402682.

In Washington, DC, the president-elect is tapping the country's brightest legal minds as candidates for the Supreme Court. Then one of them is gunned down. Another is stabbed. A third is murdered near midnight on a city street. Detective Alex Cross, the FBI's top expert in criminal behavior, is called to investigate the brutal serial killings threatening America's judicial future—but during his dangerous pursuit of the killer, his wife Bree and best friend John Sampson go missing. Cross must race to stop a diabolical conspiracy before it's too late.

The book is the inspiration for the #1 hit Amazon Prime Video streaming series Cross, starring Aldis Hodge. James Patterson is the world's most popular storyteller, the creator of the Alex Cross, Women's Murder Club, and Maximum Ride series, and the recipient of an Edgar Award, ten Emmy Awards, the Literarian Award from the National Book Foundation, and the National Humanities Medal.